Figure 2.
Clinical trial simulation of the percentage of individuals with a FLU cumulative AUC in the target range with different dosing schemas. Simulated percentage of individuals (of a study sample size of 18) with a cumulative FLU AUC in the target range of AUC of ≥13.8 to ≤25 mg × h/L using 4 different FLU dosing regimens. R1, 25 mg/m2 per day for 3 days; R2, 30 mg/m2 per day for 4 days; R3, age-adjusted dosing; or R4, TDM-guided dosing. Horizontal line, median; box, 25th to 75th percentile; whiskers, quartile range.

Clinical trial simulation of the percentage of individuals with a FLU cumulative AUC in the target range with different dosing schemas. Simulated percentage of individuals (of a study sample size of 18) with a cumulative FLU AUC in the target range of AUC of ≥13.8 to ≤25 mg × h/L using 4 different FLU dosing regimens. R1, 25 mg/m2 per day for 3 days; R2, 30 mg/m2 per day for 4 days; R3, age-adjusted dosing; or R4, TDM-guided dosing. Horizontal line, median; box, 25th to 75th percentile; whiskers, quartile range.

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