Simulated FLU AUC vs age. (A) FLU concentration vs time given 30 mg/m2 per day for 4 days based on the population PKs from Langenhorst et al.22 Curve and blue shading: median and quartile range for a person aged 5 years; curve and gray shading: median and quartile range for a person aged 15 years. (B-D) Cumulative FLU AUC vs age for different FLU dosing regimens. (B) FLU 25 mg/m2 per day for 3 days. (C) FLU 30 mg/m2 per day for 4 days. (D) Age-adjusted FLU dose (37 mg/m2 per day × 4 days for age <6 years; 33.75 mg/m2 per day × 4 days for age ≥6 but <11 years; 30 mg/m2 per day × 4 days for age ≥11 but <15 years; and 26.25 mg/m2 per day × 4 days for age ≥15 years). Panels B-D: median (black curve), 25th to 75th percentiles (blue shaded region), and 5th to 95th percentiles (gray shaded region).
