MDS platelets have altered glycan profiles. (A) Schematic diagram of lectin microarray. Lectins are color-coded based on their binding specificity. Created using BioRender.com. (B) Hierarchical heat map clustering of lectin microarray profiling of platelets collected from healthy individuals (n = 20) and patients with MDS (n = 22). Healthy individuals and patients with MDS were not matched based on sex. (C) Bar plots showing statistically significant changes in lectin binding between platelets collected from healthy individuals vs those with MDS. Binding of specific lectins is quantified based on their quantile normalized fluorescence values. Lectins are organized based on their selectivity for carbohydrate epitopes with example glycan substrates shown. ∗P < .05; ∗∗P < .01; ∗∗∗P < .001; and ∗∗∗∗P < .0001.