A novel homodimer conformation formed by 2 intermediate integrin αIIbβ3 molecules was revealed. The overall cryo-EM map of integrin αIIbβ3 in homodimer conformation at 2.85 Å resolution is shown. The top right panel is the side of the headpiece facing the cell membrane. The bottom insert shows the closeup of the dimer interface formed by 2 αIIb subunits from 2 individual integrin αIIbβ3 molecules. The residues that are involved in the dimer interface were colored in red.