Figure 5.
The architecture of integrin αIIbβ3 in the intermediate conformation and its interaction network. (A) The overall cryo-EM map of integrin αIIbβ3 in intermediate conformation at 2.67 Å resolution is shown. The right panel is the side of the headpiece facing the cell membrane. (B) Closeup of the cryo-EM density of the 4 metal ions at the β-propeller domain. (C) Closeup of the cryo-EM density of the 3 metal ions at SyMBS (Ca2+), MIDAS (Mg2+), and ADMIDAS (Ca2+) of the β-I domain. (D) 7-N-linked glycan sites within the solved region of the intermediate integrin αIIbβ3 were preserved.

The architecture of integrin αIIbβ3 in the intermediate conformation and its interaction network. (A) The overall cryo-EM map of integrin αIIbβ3 in intermediate conformation at 2.67 Å resolution is shown. The right panel is the side of the headpiece facing the cell membrane. (B) Closeup of the cryo-EM density of the 4 metal ions at the β-propeller domain. (C) Closeup of the cryo-EM density of the 3 metal ions at SyMBS (Ca2+), MIDAS (Mg2+), and ADMIDAS (Ca2+) of the β-I domain. (D) 7-N-linked glycan sites within the solved region of the intermediate integrin αIIbβ3 were preserved.

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