The interaction network of integrin αIIbβ3 in the bent conformation. (A) 11-N-linked glycan sites were preserved in the bent integrin αIIbβ3 obtained from the native environment. (B) Closeup of the cryo-EM density of the metal ions, 1 at the α-genu (top left insert), 4 at the β-propeller (top right insert), and 3 at SyMBS (occupied by a Ca²⁺), MIDAS (occupied by a Mg²⁺), and ADMIDAS (occupied by a Ca²⁺) of the β-I domain (bottom right insert). (C) A clear density of an RGD motif–containing peptide was observed in the ligand-binding site.