The overall architecture of integrin αIIbβ3 in the bent conformation. (A) The overall cryo-EM map of integrin αIIbβ3 in bent conformation at 2.75 Å resolution is shown. The integrin αIIbβ3 model was shown in ribbon diagrams with the αIIb subunit colored in royal blue and the β3 subunit colored in goldenrod here and in subsequent figures. (B) A total of 12 subdomains of the ectodomain are resolved. The integrin αIIbβ3 model was shown in ribbon diagrams with each subdomain colored as follows: β-propeller in purple, thigh in lime green, calf in light green, β-I in blue, hybrid in salmon, PSI in green, I-EGFs in yellow, and β-tail in pink. I-EGF, epidermal growth factor.