IVC ligation prolongs TXA circulation in plasma. (A-B) PA in plasma from wild-type mice treated with saline (black) or TXA (red) and 24 or 6 hours of IVC ligation; each line shows a separate mouse. (C) TXA concentration and (D) correlation of TXA concentration with plasmin peak in plasma from wild-type mice treated with saline or TXA and subjected to IVC ligation. (E) FDPs in plasma from wild-type mice treated with saline or TXA and subjected to IVC ligation. Graphs show mean ± standard deviation or median ± interquartile range, as appropriate; each dot indicates a separate mouse. Groups were compared by the ordinary 1-way analysis of variance with the Šidák multiple comparisons test or the Kruskal-Wallis test with the Dunn multiple comparisons test for normally and nonnormally distributed data, as appropriate; ∗∗P < .01, ∗∗∗P < .001.