p38γ gains proximity to OR4N5 in the CD3 of the TCR complex in CTCL Sézary cells. (A) Sézary cells from a patient with CTCL were treated with CSH71 (250 nM, right) or untreated (control, left), followed by confocal immunofluorescence analysis. OR4N5 (red) and CD3E (green) colocalize, indicated by the merged yellow signal, suggesting an interaction between p38γ and OR4N5. (B) A summary of the involvement of these molecules in the signal transduction process of SS cells (malignant T cells). A cartoon diagram illustrates the proposed molecular mechanism by which p38γ may interfere with OR dimerization via protein-protein interactions within the TCR complex via alternative p38 activation. DLGH1, also known as DLG1, Discs Large MAGUK scaffold protein 1 (Human); ITAM, Immunoreceptor Tyrosine-based Activation Motif; p-NFAT, phosphorylated nuclear factor of activated T cells.
Figure 5.

p38γ gains proximity to OR4N5 in the CD3 of the TCR complex in CTCL Sézary cells. (A) Sézary cells from a patient with CTCL were treated with CSH71 (250 nM, right) or untreated (control, left), followed by confocal immunofluorescence analysis. OR4N5 (red) and CD3E (green) colocalize, indicated by the merged yellow signal, suggesting an interaction between p38γ and OR4N5. (B) A summary of the involvement of these molecules in the signal transduction process of SS cells (malignant T cells). A cartoon diagram illustrates the proposed molecular mechanism by which p38γ may interfere with OR dimerization via protein-protein interactions within the TCR complex via alternative p38 activation. DLGH1, also known as DLG1, Discs Large MAGUK scaffold protein 1 (Human); ITAM, Immunoreceptor Tyrosine-based Activation Motif; p-NFAT, phosphorylated nuclear factor of activated T cells.

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