Synergy experiments to treat MV4-11 with HDL NPs combined with currently used agents to treat AML. MV4-11 cells were treated with HDL NPs and Cyt (A), Ven (B), and Gilt (C). Viability of the combinations at various concentrations (nanomolar) with a fixed ratio (top). Isobologram analysis of the combinations and the table represent the CI calculated by CompuSyn (bottom). ∗P < .05; ∗∗P < .01; ∗∗∗P < .001; ∗∗∗∗P < .0001. CI, combination index; Cyt, cytarabine; ED, effective dose; Gilt, gilteritinib; Ven, venetoclax.