Figure 4.
Mechanisms of cell death of MV4-11 and HEL treated with HDL NPs. (A) Annexin V–PI staining after MV4-11 cells were treated with HDL NPs from 10 to 40 nM. Apoptosis is represented by the annexin V positive PI negative population, and necrosis by the annexin V positive PI positive population. (B) Bar graph analysis of the apoptosis and necrosis results. (C) Caspase-3 and 7 levels in MV4-11 (left) and HEL (right) were detected by flow cytometry after treatment of HDL NPs from 10 to 80 nM. (D) Caspase-1 levels of MV4-11 (left) and HEL (right) after treatment of HDL NPs from 10 to 40 nM as detected by flow cytometry. (E) Representative flow cytometry results of MV4-11 (top) and (bottom) HEL cells were treated with PBS and HDL NPs (10-80 nM) stained with Live/Dead and CellROX.

Mechanisms of cell death of MV4-11 and HEL treated with HDL NPs. (A) Annexin V–PI staining after MV4-11 cells were treated with HDL NPs from 10 to 40 nM. Apoptosis is represented by the annexin V positive PI negative population, and necrosis by the annexin V positive PI positive population. (B) Bar graph analysis of the apoptosis and necrosis results. (C) Caspase-3 and 7 levels in MV4-11 (left) and HEL (right) were detected by flow cytometry after treatment of HDL NPs from 10 to 80 nM. (D) Caspase-1 levels of MV4-11 (left) and HEL (right) after treatment of HDL NPs from 10 to 40 nM as detected by flow cytometry. (E) Representative flow cytometry results of MV4-11 (top) and (bottom) HEL cells were treated with PBS and HDL NPs (10-80 nM) stained with Live/Dead and CellROX.

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