AML cell lines are exquisitely sensitive to HDL NP treatment. (A) MTS viability assay of MV4-11 (top), HEL (middle), and U937 (bottom) treated with HDL NPs (left) or cytarabine (right) at various nanomolar or micromolar concentrations. (B) Colony-forming assays with MV4-11 cells grown in methylcellulose treated with or without HDL NPs at 50 nM. CFUs are highlighted by red outlines on well images (left). The total CFU count (top right) and area (bottom right) were significantly reduced when treated with HDL NPs. (C-D) Representative images for HEL and U937 with or without HDL NP and total CFU areas. ∗P < .05; ∗∗∗P < .001. CTRL, control.

AML cell lines are exquisitely sensitive to HDL NP treatment. (A) MTS viability assay of MV4-11 (top), HEL (middle), and U937 (bottom) treated with HDL NPs (left) or cytarabine (right) at various nanomolar or micromolar concentrations. (B) Colony-forming assays with MV4-11 cells grown in methylcellulose treated with or without HDL NPs at 50 nM. CFUs are highlighted by red outlines on well images (left). The total CFU count (top right) and area (bottom right) were significantly reduced when treated with HDL NPs. (C-D) Representative images for HEL and U937 with or without HDL NP and total CFU areas. ∗P < .05; ∗∗∗P < .001. CTRL, control.

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