SR-B1 expression is elevated in AML cells, targeted by bioinspired gold-core HDL NPs. (A) HDL NPs comprise a 5 nm gold NP core surface functionalized with ApoA-I and phospholipids. After the stepwise addition of the components and self-assembly, HDL NPs are purified by tangential flow filtration. (B) In the LAML database in Gene Expression Profiling Interactive Analysis, there was a significant reduction in OS with patients expressing higher SR-B1 levels than those with AML with lower SR-B1 expression. (C) SR-B1 expression by flow cytometry in AML cell lines MV4-11, HEL, U937 compared with SR-B1^– U266B1 and SR-B1⁺ Ramos cells presented as a histogram (left) and MFI (right). ApoA-I, apolipoprotein A1; HR, hazard ratio.