Hemostatic adjuncts alter clot initiation, not terminal clot morphology during resuscitation of in vitro–induced dilutional coagulopathy. Locally estimated scatterplot smoothing fit of normalized traces (N = 3 to 6) of MFI over time (frame rate of 0.12 s⁻¹) represented as percentage (%) of maximum signal for VWF and platelets in (A) rCryo:dWB and (B) rFibCon:dWB at each of the 3 shear rates (3500 s⁻¹ [top], 500 s⁻¹ [middle], and 150 s⁻¹ [bottom]) for the first 10 minutes of each assay. Voxels from 3-dimensional space filling models of z-stack fluorescent images of the injury site were used to calculate the volumetric contributions of (C) platelets and (D) VWF, as well as to determine (E) injury site clot volume of terminal clots formed in rCryo:dWB (N = 6) and rFibCon:dWB (N = 3). Data are represented as mean (standard deviation); rCryo:dWB and rFibCon:dWB were compared at each shear rate using an unpaired Student t test. (F) Volumetric contributions of PLT (platelets), VWF, FGN, and FXIII expressed as a proportion of the injury site clot volume in clots from both rCryo:dWB and rFibCon:dWB at all 3 shear rates. FGN, fibrinogen.