Figure 1.
Experimental methods. (A) Imaging of a single RBC traversing the microfluidic constriction. Scale bar, 10 μm. (B) Calculation of single-cell oxygen saturation uses absorption from a 410-nm light-emitting diode (LED) to calculate mass of oxygenated Hb, and absorption from a 430-nm LED to calculate mass of deoxygenated Hb. (C) The single-cell deformation is measured by calculating the absolute difference in cell Taylor deformation within the constriction and outside the constriction. (D) RBCs are classified as either sickled or nonsickled using a ResNet-50 CNN.

Experimental methods. (A) Imaging of a single RBC traversing the microfluidic constriction. Scale bar, 10 μm. (B) Calculation of single-cell oxygen saturation uses absorption from a 410-nm light-emitting diode (LED) to calculate mass of oxygenated Hb, and absorption from a 430-nm LED to calculate mass of deoxygenated Hb. (C) The single-cell deformation is measured by calculating the absolute difference in cell Taylor deformation within the constriction and outside the constriction. (D) RBCs are classified as either sickled or nonsickled using a ResNet-50 CNN.

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