Location of each variant analyzed and its respective VWF:pp/VWF:Ag and VWF:CB/VWF:Ag ratios. (A) The VWF:pp/VWF:Ag ratio of the Gly1672Arg and Arg1943Cys variants was >1.6, suggesting abnormality with enhanced clearance. (B) The VWF:CB/VWF:Ag ratios of Arg1145Cys and Ala1461Val were below the threshold value of 0.7, suggesting molecular abnormalities.