Analysis of the expression of HERVs and embryonic genes in patients treated with chemotherapy and ibrutinib according to partial and complete remission. (A) Analysis of lymphocyte number at the time of sampling in patients with CLL divided by treatment regimen stratified by remission condition. (B) Regarding the analysis of HERVs expression, no significant difference was found between patients in partial and complete remission in both chemotherapy- and ibrutinib-treated patients. (C) Among embryonic genes, only NANOG expression was significantly higher in patients who received chemotherapy and in complete remission compared than those in partial remission. For lymphocyte count, nonparametric Mann-Whitney test was used to compare the groups; association with remission status was analyzed in multivariate general linear models. Statistical significance was set as follows: P < .050.