Principal component analysis (PCA) plot of multiancestry participants in the ODSCS. PCA plots were generated for study participants along with individuals from the 1000 Genomes Project reference populations (gray). Color labels correspond to self-reported race/ethnicity of study participants. PCA plots were generated separately for newborns with GATA1s mutations (left, n = 103) and GATA1 wild-type controls (right, n = 326). PCs were calculated using PLINK, and plots were generated using R.