Schematic representation of the mechanisms of action of Cile and Bexa in TCL cells. (1) THs by acting through integrin αvβ3 increase STAT1, STAT3, and STAT5 phosphorylation, upregulate mRNA levels of CCR4, GATA3, MMP2, MMP9, VEGFA, and CCND1, and induce metalloprotease activity in TCL supernatants. (2) The pharmacological inhibition of integrin αvβ3 in combination with Bex decreased in vivo TCL dissemination by inducing a proteomic profile associated with the inhibition of biological processes such as cell proliferation, angiogenesis, metastasis, and lymphoma progression. TR, thyroid hormone nuclear receptor.