Differential intensity and patterns of immune cell interaction in the 2 groups. (A-B) Outgoing and incoming interaction strength of each immune cell subset of the HA (A) and HB (B) groups were visualized by 2-dimensional dot plot. (C-D) The heat maps showed overall signaling patterns with strength of each subset in HA (C) and HB (D). (E) Compared strength of axes of APC and monocyte communication with naïve CD4⁺ T cells. (F) Compared strength of axes of APC and monocyte communication with CD4⁺ Th cell. (G) Compared strength of axes of CD4⁺ Th cell communication with B-cell subsets.