Differential functional status and BCR diversity of B cells between HA and HB groups. (A-B) IGHC genes sequenced by scBCR-seq of corresponding B cells and plasma cells were shown on the UMAP. (C) The cell ratios of each B-cell and plasma cell subset in each sample. (D-F) The volcano plots were used to visualize the DEGs and their P values and FCs of the 3 B-cell subsets including B_1 (D), B_2 (E), and B_3 (F) between the 2 groups. (G-H) The bar plots showed the GO_BP pathways enriched by all DEGs of the 3 B-cell subsets in HA (G) and HB (H) groups; FDR <0.05 were considered significant. (I) Numbers of unique B-cell clonotypes in the HA and HB groups. (J) Top clonal proportions of B-cell clonotypes with specific indices of each sample. (K) Rare clonal proportions of B-cell clonotypes with specific counts of each sample. FC, fold change; FDR, false discovery rate; MAX, maximum.