Mutational landscape of the development cohort at first AML diagnosis. Driver events found at diagnosis in 943 patients with relapsed AML. Each bar represents a driver lesion, including gene mutations, and chromosomal abnormalities. abn, abnormality in; ck, complex karyotype (annotated according to the 2022 ELN risk classification); del, deletion in; inv, inversion of; mk, monosomal karyotype; m, monosomy; t, translocation of.