Expression of T-cell exhaustion markers in CD8 T cells according to CHIP status. (A) Dot plot displaying the expression of selected marker genes in CD8 T precursor exhausted cells of CHIP-positive and CHIP-negative samples. The X-axis lists gene names, whereas the Y-axis lists the CHIP status. Circle size corresponds to the percentage of cells in the category expressing the gene of interest, whereas shade correlates with the level of expression. (B) Violin plot depicting the T-cell dysfunction score computed in CD8 T-cell subpopulations of CHIP-negative and CHIP-positive samples. ∗adjusted P value <.05; ∗∗∗adjusted P value <.001.