Single-cell transcriptomic characterization of the clonal BM microenvironment. (A) Cartoon depicting selected hallmark gene sets related to inflammatory response and significantly upregulated in ≥2 of the depicted cell types in CHIP-positive patients. Circle size corresponds to the number of cells in the category expressing the genes of interest, whereas the color represents the P value, as detailed in the legend of each of the GSEA analyses reported in supplemental Figure 3A-E. (B) Violin plot representing the distribution of peptide antigen binding score in myeloid DCs (Prog_DCs and cDC2) according to the occurrence of CHIP. (C) Violin plot representing the distribution of M1 macrophage polarization score (supplemental Methods) in CD14 and CD16 monocytes according to the occurrence of CHIP. ∗adjusted P value <.05; ∗∗∗adjusted P value <.001. GSEA, gene set enrichment analysis.