Figure 4.
Cellular composition of the BM microenvironment. (A) 2D UMAP representation of the 132 752 analyzed cells color coded by assigned cell type (left), patient (top right), or relative CHIP status (bottom right). (B) Box plot revealing the relative abundance of different T and NK cell subtypes between CHIP-negative (bright blue) and CHIP-positive (deep red) patients. ∗adjusted P value <.05; ∗∗∗adjusted P value <.001. gdT, gamma-delta T cells; MAIT, mucosa-associated invariant T cells; UMAP, uniform manifold approximation and projection.

Cellular composition of the BM microenvironment. (A) 2D UMAP representation of the 132 752 analyzed cells color coded by assigned cell type (left), patient (top right), or relative CHIP status (bottom right). (B) Box plot revealing the relative abundance of different T and NK cell subtypes between CHIP-negative (bright blue) and CHIP-positive (deep red) patients. ∗adjusted P value <.05; ∗∗∗adjusted P value <.001. gdT, gamma-delta T cells; MAIT, mucosa-associated invariant T cells; UMAP, uniform manifold approximation and projection.

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