Upon single stem cell transplantation (Lin^-Sca-1⁺c-Kit⁺CD150⁺48^-CD201⁺, called ESLAM LSK) in a mouse model, HSC clones can be categorized into 3 distinct types based on their ability to produce blood cells: SUPER, FLASH and TRICKLE. These clones exhibit either balanced (multilineage) or biased (lineage restricted) differentiation potential. Each clone type demonstrates unique transplantability and contributes differently to blood production during serial transplantation. The functional properties of these HSC clones are driven by distinct molecular signatures (blue-low expression, red-high expression). Professional illustration by Patrick Lane, ScEYEnce Studios.