IMG based on IG (left) and TR (right) rearrangements in B-ALL and T-ALL cases. The most mature rearrangement identified for each patient determines the IMG for that individual. The IMG and corresponding rearrangements are ordered (left to right) by their appearance during the physiological B-cell (A) and T-cell (B) development. (C-D) The distribution by age of the IG-based IMG in patients with B-ALL (C) and the TR-based IMG in patients with T-ALL (D) is shown. (E-F) The distribution in pediatric and adult patients of the IG-based IMG in patients with B-ALL (E) and the TR-based IMG in patients with T-ALL (F) is illustrated. Patient numbers are shown within each bar. P values were corrected for multiple testing using the Bonferroni method. Statistical significance is indicated as follows: ns, P > .05; ∗P ≤ .05; ∗∗P ≤ .01; ∗∗∗P ≤ .001. c, complete; i, incomplete; max, maximum; ns, not significant; TRG, T-cell receptor γ rearrangement; yo, years old.