PFS and OS by risk category using the PET-based score compared with FLIPI-2 in the E2408 cohort. (A) PFS using the PET-based score. The KM Ests are shown with 2-year PFS of 70% in the high-risk group (score, 4-6), 87% in the intermediate-risk group (score, 2-3), and 91% in the low-risk group (score, 0-1). (B) PFS using FLIPI-2. The KM Ests are shown with 2-year PFS of 79% in the high-risk group (score, 3-5), 85% in the intermediate-risk group (score, 1-2), and 100% in the low-risk group (score, 0). (C) OS using the PET-based score. The KM Ests are shown with 2-year OS of 82% in the high-risk group, 93% in the intermediate-risk group, and 97% in the low-risk group. (D) OS using FLIPI-2. The KM Ests are shown with 2-year OS of 87% in the high-risk group, 93% in the intermediate-risk group, and 100% in the low-risk group. CI, confidence interval; Est, estimate; KM, Kaplan-Meier; NE, not estimable.