Figure 4.
Production and activity of FVIII disulfide bond mutants. (A) WT, C1918A,C1922A, C2040A,C2188A, or C2193A,C2345A disulfide mutant human B domain–deleted FVIII protein secreted by Flp-InTM 293 cells. The data are from 4 to 11 independent experiments and bars and errors are mean ± SD. (B) Activity of WT, C1918A,C1922A, and C2040A,C2188A FVIII protein in FVIII-depleted plasma measured by the formation of FXa. The data are from 3 independent experiments and bars and errors are mean ± SD.

Production and activity of FVIII disulfide bond mutants. (A) WT, C1918A,C1922A, C2040A,C2188A, or C2193A,C2345A disulfide mutant human B domain–deleted FVIII protein secreted by Flp-InTM 293 cells. The data are from 4 to 11 independent experiments and bars and errors are mean ± SD. (B) Activity of WT, C1918A,C1922A, and C2040A,C2188A FVIII protein in FVIII-depleted plasma measured by the formation of FXa. The data are from 3 independent experiments and bars and errors are mean ± SD.

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