Figure 3.
Reinitiation and dynamics of response per patient. For patients in arm B (treatment cessation), (A) time to reinitiation of treatment per protocol is provided. For those who did not reinitiate treatment, (B) MRD kinetics are provided. Please note that 4 patients met the dMRD2 criteria without reinitiating therapy (see text for details). (C) Dynamics of MRD until reinitiation for the patients reinitiating treatment per protocol, dashed lines indicate the level of dMRD for individual patients at time of reinitiating therapy, whereas (D) provides the MRD kinetics for those patients after reinitiation. Data cutoff for panels B-D is 24 October 2023, MRD results tested every 3 to 4 months. MRD levels are indicated, MRD2 = 1% = 10−2, MRD3 = 0.1% = 10−3, and MRD4 = 0.01% = 10−4.