BMP-eBM shows an aging phenotype change similar to LB-BM. (A-C) Analysis of BMP-eBM aging compared with LB-BM. BMP-eBM was harvested 4 or 52 weeks after implantation. LB-BM was harvested from C57BL6J mice at 10 or 50 weeks of age. (A) HE staining images. Lower panels are high-magnification images of the squares shown in the upper images. (B) Quantification of bone area and adipocyte area per total area of the image shown in the lower panel of A (n = 4). (C) Frequency of HSCs, total B cells, and myeloid cells (n = 3-4).