Pts with MDS exhibit reduced quantity and quality of cDC populations. (A) Percentage of cDC1 (left) and cDC2 (right) population in the peripheral blood of Pts receiving DVN. Dotted lines depict frequencies of peripheral cDC1 and cDC2 populations in HDs as previously reported.32 (B) Expression of cDC genes associated with costimulation (CD80, CD86, ICOSLG, and CD40), exhaustion (PD-L1), and immune cell recruitment (CXCL9) in bone marrow cDC1 and cDC2 populations in HDs (blue circles) vs Pts with MDS (red circles). Expression was quantified using data mined from publicly available bulk RNA sequencing performed on sorted cDC1 and cDC2 populations derived from low cell numbers, as previously reported by Srivastava et al (GSE131792).41 FPKM, fragments per kilobase per million mapped fragments; PD-L1, programmed death ligand-1.