Survival outcome of TP53^mut AML was poor irrespective of allelic status and CK status. (A) The median OS of TP53^mut AML with VAF ≥10% was significantly poor compared with AML with a VAF <10%. (B) CK was more prevalent in AML cases with biallelic compared with those with monoallelic inactivation. In AML with a VAF ≥10%, the median OS was similar in (C) cases with or without CK, and (D) biallelic and monoallelic inactivation. (E) Similarly in AML with a VAF <10%, median OS was comparable regardless of CK status. 95% CI, 95% confidence interval; NA, not available.