Further stratification of TP53^mut MDS-LB by allelic status, CK, and VAF. (A) The median OS for patients with biallelic TP53 inactivation was significantly shorter compared with those with monoallelic inactivation. (B) Among patients with TP53 monoallelic inactivation, those with CK had a significantly shorter median OS compared with those without CK. Notably, their OS was comparable to that of patients with biallelic inactivation. (C) The median OS for patients with TP53^mut VAF ≥10% was significantly poor compared with those with a VAF <10%. (D) Biallelic TP53 inactivation was more prevalent in cases with a VAF ≥10% compared with those with a VAF <10%. 95% CI, 95% confidence interval; NA, not available.