Characterization of TP53^mut MNs. (A) TP53^mut AML was highly prevalent followed by MDS-LB, -EB2, and -EB1, respectively. (B) The VAF was significantly higher in AML and MDS-EB2 compared with MDS-LB. (C) 17p loss was more prevalent in cases with single TP53^mut. (D) Most TP53^mut cases exhibited biallelic inactivation. (E) The frequency of biallelic inactivation increased with higher blast categories.