Figure 5.
STAMP-treated patient cells exhibited a reduction in pSTAT5 levels. Representative histograms of the intracellular flow cytometry of ZC3HAV1::ABL2 patient cells treated with 5 μM asciminib (A) or 5 μM TERN-701 (C) and stained with anti-pSTAT5 antibody. Corresponding column graphs of the MFI values for pSTAT5 for the asciminib (B) and TERN-701 treated cells (D) normalized to the untreated control. All experiments were performed in biological replicates (n = 3), and statistical significance was calculated using the unpaired Student t test. ∗P < .05; ∗∗∗P < .001; ∗∗∗∗P < .0001.

STAMP-treated patient cells exhibited a reduction in pSTAT5 levels. Representative histograms of the intracellular flow cytometry of ZC3HAV1::ABL2 patient cells treated with 5 μM asciminib (A) or 5 μM TERN-701 (C) and stained with anti-pSTAT5 antibody. Corresponding column graphs of the MFI values for pSTAT5 for the asciminib (B) and TERN-701 treated cells (D) normalized to the untreated control. All experiments were performed in biological replicates (n = 3), and statistical significance was calculated using the unpaired Student t test. ∗P < .05; ∗∗∗P < .001; ∗∗∗∗P < .0001.

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