An “hPC” signature analysis allows prediction in independent data sets. (A) HD gene signature defined by a DE analysis between HDs and MGUS, SMM, and MM. For each contrast genes significantly upregulated in HDs (Benjamini-Hochberg adjusted P < .05; log fold change >0.1) were retained. Venn diagram to show the intersection of deregulated genes within each comparison. Color code as shown Figure 1C. (B) Violin plot showing the inference of HD in the cohort of patients. (C-D) Clinical impact of HD signature in CoMMpass RNA-seq data. PFS (C) and OS (D) Kaplan-Meier curves in the cohort of patients. OS, overall survival; PFS, progression-free survival. Time is measured in years.