Predicted interactions of PCs with microenvironment. (A) UMAP representation of PCs integrated with TME, colors indicate TME cell types. (B) UMAP plot of PCs integrated with TME colored according to immunoparesis. Color code as shown in Figure 4C. (C-D) Circos plots illustrate ligand-receptor interactions between pPCs (blue), cPCs (red), and TME, according to presence or absence of immunoparesis. Ribbon arrows indicate directionality of communication, from sender to receiver populations, whereas the arrow’s color signifies the specific sender cell type expressing the ligand. PCs were set as senders (C) and as receivers (D). DC, dendritic cells; gdT, γδ T cells; ProgB, B-cell progenitors; ProgMK, megakaryocyte progenitors; Treg, T-regulatory cells.