Transcriptomic landscape of immunoparesis. (A) Cartoon showing the pathological subset of patients (MGUS, SMM, and MM), for downstream DE analyses. Color code as shown in Figure 1C. (B) Dot plot of top 10 marker genes that distinguish patients with and without immunoparesis. The x-axis lists the clinical category, whereas the y-axis lists gene names. Circle size corresponds to the number of cells in the category expressing the gene of interest, whereas shade correlates with the level of expression. (C) DE analysis comparing the patients with or without immunoparesis within a symptomatic subset of patients, using Wilcoxon rank sum test, with adjusted P value Benjamini-Hochberg correction. No immunoparesis, blue; immunoparesis, yellow. (D) GSEA on the genes ranked by their contribution to hallmark oxidative phosphorylation, complement and IFN-γ response. NES, normalized enrichment score.