Transcriptional characterization of pPCs. (A) Cartoon depicting the deregulated expression profiles of pPCs, derived from 1:1 DE analyses by Wilcoxon test. Circle size corresponds to the number of cells in the category expressing the gene of interest, whereas shade correlates with the level of expression. Color code as in Figure 1C. (B-D) Gene set enrichment analysis (GSEA) plots depicting the enrichment of signal pathways based on the hallmark gene set. NES, normalized enrichment score.