Clonal and polyclonal cells identification in patients affected by PC dyscrasias and HD. (A) Schematic overview of cohort of samples and workflow of the study. (B) Donut charts representing the distribution of polyclonal (blue) and clonal cells (red) in PC dyscrasias and HDs. Numerical values are reported. (C) The proportions of clonal cells (red) and polyclonal cells (blue) in each sample, categorized by clinical state (top). (D) UMAP plot showing all clonal (red) and polyclonal (blue) cells, with numerical values. (E) UMAP representation of the sample space categorized by disease stage. Colors as in panel C. Numerical values and percentages are reported for each category. (F) Violin plots showing distribution of expression of genes commonly upregulated in patients with PC dyscrasias, along with annotations of the clinical classification (top). BM, bone marrow; df, degrees of freedom.