Differential protein expression in DE and non-DE DLBCL samples. (A) Bar plots showing the statistical analysis of indicated protein expression in DE and non-DE DLBCL samples. (B) The differential expression of indicated functional markers in various cell types between DE and non-DE DLBCL samples. (C) IHC was performed to validate the expression of p-S6 in 18 DLBCL specimens, and 4 representative images of p-S6 staining were shown to validate IHC staining scores. (D) Survival analysis of 71 patients with DLBCL in our respective study was performed using GraphPad Prism software (version 8). (E) Overall survival (OS) and disease-specific survival analysis of p-S6 (235/236). Protein arrays data were performed on TRGAted (https://nborcherding.shinyapps.io/TRGAted/). Grouping by “auto select best cutoff.” (F) Univariate analysis of The Cancer Genome Atlas database. HR >1 is poorly prognostic; HR <1 indicated improved OS and any characteristic crossing the line at 1 is not significant. CR, complete response; HR, hazard ratio; PD, progressive disease; PR, partial response; SD, stable disease. ∗p < .05; ∗∗∗p < .001; ∗∗∗∗p < .0001.