LIRS further refines ELN by treatment intensity. LIRS score split into high-, medium-, and low-risk group by score tertile defined in the training cohort. (A) Kaplan-Meier curve showing OS of LIRS in only patients receiving an intensive induction regimen. (B) Kaplan-Meier curve showing OS of LIRS in patients receiving an intensive induction regimen and within ELN2022 favorable risk. (C) Kaplan-Meier curve showing OS of LIRS in patients receiving an intensive induction regimen and within ELN2022 intermediate risk. (D) Kaplan-Meier curve showing OS of LIRS in patients receiving an intensive induction regimen and within ELN2022 adverse risk. (E) Reclassification by LIRS groups for ELN2022 risk group in patients receiving an intensive induction regimen. (F) Model performance of LIRS, the ELN2022, and ELN2022 combined with LIRS, by C-index in patients receiving an intensive induction regimen. (G) Kaplan-Meier curve showing OS of LIRS in only patients receiving a nonintensive induction regimen. (H) Kaplan-Meier curve showing OS of LIRS in patients receiving a nonintensive induction regimen and within ELN2024 favorable risk. (I) Kaplan-Meier curve showing OS of LIRS in patients receiving a nonintensive induction regimen and within ELN2024 intermediate risk. (J) Kaplan-Meier curve showing OS of LIRS in patients receiving a nonintensive induction regimen and within ELN2024 adverse risk. (K) Reclassification by LIRS groups for ELN2024 risk group in patients receiving a nonintensive induction regimen. (L) Model performance of LIRS, the ELN2024, and ELN2024 combined with LIRS, by C-index in patients receiving a nonintensive induction regimen.