Mutational landscape of DR and DE disease. The table shows mutations found in ≥5% of the study population or those with known pathogenic roles in CLL and histologic transformation (eg, CDKN2A, MAP2K1). Mutations detected at any time point during the disease course were included in this analysis. ∗Pearson χ² test or Fisher exact test. ∗∗BTK and PLCG2 sequencing was performed in 22 DR and 30 DE patients.