Figure 4.
![T-ALL significantly alters the composition of the CNS myeloid compartment. (A-F) Quantification of frequencies of the indicated myeloid subsets within the CNS myeloid compartment of F1 mice engrafted with LMO2 T-ALL vs healthy littermates. Myeloid cells were analyzed by flow cytometry (supplemental Figure 2) to determine the frequencies of macrophages (A), Ly6Chigh monocytes (B), Ly6Clow monocytes (C), DCs (D), granulocytes (E), and microglia (F). Bars represent mean + SEM of cumulative data from 5 independent primary T-ALL stocks and 4 healthy littermates. ∗P < .05; ∗∗P < .01; ∗∗∗P < .001; ∗∗∗∗P < .0001 (using the unpaired Student t test [Mann-Whitney U] in panels A-F).](https://ash.silverchair-cdn.com/ash/content_public/journal/bloodneoplasia/2/3/10.1016_j.bneo.2025.100095/1/bneo_neo-2024-000479-gr4.jpeg?Expires=1752324459&Signature=sygxCI-o~SNkbo3FhfegEbh~jdcZivtlYAPtJ2gpat0p2DmzyThLOR6vxn6tHaPineMOXfdRAVYoJ2phEt10JzurT8He6TmgmEQ6DsXF2bWwfpN1T0bQRfYkUSvedKvMSVqbhCWuyRwrk50Qrh3g-TBKFl062P6bi-yhAwALsUxKKjaoNHc4MnDASCsgqyS4JReNDsR0bz0l9bHDzgYw38u~eZh2X1ftWEqLOKv0PD0PM3Mis9R6T~ZX7LtSqOqGXhhQJGtKsNaCAjZGS7jbKUHAiEhpSGxJP6eaB9by5a0Kikl4ohAyPgcc2JRsHMX8e96-YrlT2O~OjcQb6OwZRg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
T-ALL significantly alters the composition of the CNS myeloid compartment. (A-F) Quantification of frequencies of the indicated myeloid subsets within the CNS myeloid compartment of F1 mice engrafted with LMO2 T-ALL vs healthy littermates. Myeloid cells were analyzed by flow cytometry (supplemental Figure 2) to determine the frequencies of macrophages (A), Ly6Chigh monocytes (B), Ly6Clow monocytes (C), DCs (D), granulocytes (E), and microglia (F). Bars represent mean + SEM of cumulative data from 5 independent primary T-ALL stocks and 4 healthy littermates. ∗P < .05; ∗∗P < .01; ∗∗∗P < .001; ∗∗∗∗P < .0001 (using the unpaired Student t test [Mann-Whitney U] in panels A-F).
