Age-dependent hematologic changes in control (AA) and sickle trait (AS) mice. Hematology profiles for AA (gray bars) and AS mice (blue bars) are shown for mice (n = 6-10) aged 8 weeks (open bars) and 40 weeks (striped bars). Values are shown as mean ± SEM. ∗P < .05; ∗∗P < .01; ∗∗∗P < .001; ∗∗∗∗P < .0001. Hct, hematocrit; MCH, mean corpuscular Hb; MCHC, mean corpuscular Hb concentration; MCV, mean corpuscular volume; MPV, mean platelet volume; RDW, red cell distribution width.