LY500307 sensitizes CTCL cells to chemotherapeutic agents. Antiproliferative effect of LY500307 and/or chemotherapeutic agent compared with placebo in CTCL cells, determined by performing MTS assays. Cells were treated with either vehicle or LY500307 and chemotherapeutics at different concentrations for 48 hours. The degree of synergy was quantified as CI using the Chou-Talalay method, from dose-response curves with constant ratios of agents tested (CI = 1 indicates a purely additive effect; CI < 1 reveals synergy). Mean value of 3 independent experiments with SD is plotted.