TTNT by study period. The Kaplan-Meier plot illustrates TTNT, stratified by the study period during which 1L treatment was administered, reflecting the Israeli reimbursement policy in effect at the time of diagnosis. The red curve represents patients diagnosed between 2014 and 2018, the blue curve represents those diagnosed between 2019 and 2022, and the green curve represents patients diagnosed since 2023. The table below shows the number of patients at risk (individuals who have not yet progressed to second-line treatment and are still under observation) at each time point. The P value represents the result of the log-rank test comparing the survival curves.