TTNT by age group. The Kaplan-Meier plot illustrates TTNT stratified by age group. The blue curve represents the Octo cohort (aged ≥80 years), whereas the red curve represents the OL cohort (aged 70 to <80 years). The table below displays the number of patients at risk (individuals who have not yet progressed to second-line treatment and are still under observation) at each time point. The P value represents the result of the log-rank test comparing the survival curves.