Mutational and ELN risk profile of patients with MPN-AP/BP. (A) Oncoprint shows an integrated annotation of mutations and ELN risk categories. Patients are organized in columns with genes labeled along the rows. Bar plots illustrate the mutations per patient (top) and the frequency of mutations in the cohort (right). ELN risk classifications are color-coded (bottom). The green square marks a mutated gene. (B) The Sankey plot displays the changes in risk assignment across the 2017, 2022, 2024, and refined 2024 ELN criteria. (C) Dot plot representation of the mutation frequency in the BEAT AML cohort of patients and MPN AP/BP patients. Overlapping sequenced genes are depicted.